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CONFORMATION OF XYLOCHOLINE

被引：19
作者：
COGGON, P
MCPHAIL, AT
ROE, AM
机构：
[1] Department of Chemistry, Duke University, Durham, NC
[2] Research Institute, Smith Kline and French Laboratories Limited, Welwyn Garden City
来源：
NATURE | 1969年 / 224卷 / 5225期
关键词：
D O I：
10.1038/2241200a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
THE biological activity of quaternary aryloxyethylammonium salts is critically dependent on the nature and position of the substituents in the aromatic ring1-3. Thus choline phenyl ether bromide is a potent nicotine-like ganglion stimulant2,4, whereas its 2,6-dimethyl analogue (xylocholine) is devoid of ganglion stimulant activity5 but was the first compound to exhibit adrenergic neurone blocking activity6-9. Xylocholine also has muscarine-like properties6-9. © 1969 Nature Publishing Group.
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页码：1200 / &
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