SEPARATION AND DETERMINATION OF TESTOSTERONE AND TESTOSTERONE ESTERS IN SELECTED PHARMACEUTICAL FORMULATIONS

被引：7

作者：

GRAHAM, RE ^{[1
]}

BIEHL, ER ^{[1
]}

KENNER, CT ^{[1
]}

机构：

[1] SO METHODIST UNIV, DEPT CHEM, DALLAS, TX 75275 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 07期

关键词：

Chromatography; column—analysis; testosterone and testosterone esters; various Pharmaceuticals; acetonitrile‐infusorial earth column; Testosterone esters—analysis; acetonitrile‐infusorial earth column chromatography; separation from testosterone esters; Testosterone—analysis; various pharmaceuticals;

D O I：

10.1002/jps.2600680722

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A rapid quantitative procedure is presented for the separation of testosterone esters from their hydrolysis products through the use of the acetonitrile‐infusorial earth column. The method was applied to testosterone cypionate, testosterone enanthate, and testosterone propionate. Recovery and replication of reference standard testosterone and its three esters through the proposed method ranged from 99.1 to 100.3%, and the percent relative standard deviation ranged from 0.6 to 1.0%. Two samples can be separated into testosterone and testosterone ester fractions in about 1.5 hr. The analyses of 20 injectable and one buccal tablet formulations made by 12 different manufacturers are reported. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：871 / 875

页数：5

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[2]

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[3]

CAROL J, 1953, J ASSOC OFF AGR CHEM, V36, P1001

[4]

CAVINA G, 1971, FARM ED PRAT, V26, P275