EFFECT OF HISTAMINE ON LEUKOCYTE MIGRATION TEST IN MAN .1. DEMONSTRATION OF A LIF PRODUCTION INHIBITOR (LIF-PI)

被引：21

作者：

RIGAL, D

MONIER, JC

SOUWEINE, G

机构：

[1] Laboratoire de Médecine Préventive, Faculté de Médecine Alexis Carrel, 69372 Lyon Cedex 2, Rue Guillaume Paradin

来源：

CELLULAR IMMUNOLOGY | 1979年 / 46卷 / 02期

关键词：

D O I：

10.1016/0008-8749(79)90423-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The inhibition by BCG of leukocyte migration was abolished by histamine in human donors with a positive tuberculin skin test. This effect was related to two mechanisms: a direct stimulation of polynuclear cell migration by histamine, and the production of a LIF production-inhibiting soluble factor (LIF-PI) by nylon-adherent T lymphocytes with receptors for histamine. This factor was not dialyzable, had a molecular weight below 50,000, and was absorbed on aggregated human immunoglobulins. Cells which produced this factor behaved as suppressors of the in vitro human delayed hypersensitivity reaction. © 1979.

引用

页码：360 / 372

页数：13

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