AUTOANTIBODIES IN PRIMARY BILIARY-CIRRHOSIS - ANALYSIS OF REACTIVITY AGAINST EUKARYOTIC AND PROKARYOTIC 2-OXO ACID DEHYDROGENASE COMPLEXES

被引:25
作者
FUSSEY, SPM
LINDSAY, JG
FULLER, C
PERHAM, RN
DALE, S
JAMES, OFW
BASSENDINE, MF
YEAMAN, SJ
机构
[1] UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT BIOCHEM & GENET,NEWCASTLE TYNE NE2 4HH,ENGLAND
[2] UNIV NEWCASTLE UPON TYNE,DEPT MED,NEWCASTLE TYNE NE2 4HH,ENGLAND
[3] UNIV GLASGOW,DEPT BIOCHEM,GLASGOW G12 8QQ,SCOTLAND
[4] UNIV CAMBRIDGE,DEPT BIOCHEM,CAMBRIDGE CB2 1QW,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1016/0270-9139(91)90300-K
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Six components of the mammalian 2-oxo acid dehydrogenase complexes have previously been identified as M2 autoantigens in primary biliary cirrhosis. In this report, we present data showing that both polypeptide-specific and cross-reacting antibodies are present in patients' sera. Antibodies reacting with E2 of the pyruvate dehydrogenase complex corss-react with protein X but not with any other mammalian antigen. The main immunogenic region on protein X has been localized to within its single lipoyl domain. Polypeptide-specific antibodies bind to E1-alpha and E1-beta of the pyruvate dehydrogenase complex. Antibodies reacting with the E2 polypeptides of the 2-oxoglutarate dehydrogenase complex and branched-chain 2-oxo acid dehydrogenase complex show some cross-reactivity but do not recognize any of the antigens of the pyruvate dehydrogenase complex. Antibodies against the E2 component of the mammalian pyruvate dehydrogenase complex cross-react effectively with the corresponding protein from yeast but not with E2 from Escherichia coli. Antibody titer against mammalian antigens is significantly higher than against the bacterial antigens, arguing against a bacterial origin for primary biliary cirrhosis.
引用
收藏
页码:467 / 474
页数:8
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