TUMORS OF MESOTHELIAL ORIGIN IN RATS FOLLOWING INOCULATION WITH BIOGENIC SILICA FIBERS

被引：8

作者：

BHATT, TS

LANG, S

SHEPPARD, MN

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT HISTOPATHOL,LONDON EC1A 7BE,ENGLAND

[2] ROYAL BROMPTON NATL HEART & LUNG HOSP,DEPT HISTOPATHOL,LONDON SW3 6NP,ENGLAND

来源：

CARCINOGENESIS | 1991年 / 12卷 / 10期

关键词：

D O I：

10.1093/carcin/12.10.1927

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pleural implant experiments using Sprague-Dawley rats have shown that those injected with the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenenthren-17-one (11-methyl-17-ketone) intraperitoneally followed by silica fibres intrapleurally develop mesotheliomas. These tumours were histologically similar to those induced by crocidolite alone. The intraperitoneal injection of 11-methyl-17-ketone also induced leukaemia.

引用

页码：1927 / 1931

页数：5

共 31 条

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