EFFECTS OF LONG-TERM TREATMENT WITH WARFARIN ON FIBRINOGEN, FPA, TAT, AND D-DIMER IN PATIENTS WITH CORONARY-ARTERY DISEASE

被引：22

作者：

ERITSLAND, J ^{[1
]}

SELJEFLOT, I ^{[1
]}

ARNESEN, H ^{[1
]}

SMITH, P ^{[1
]}

WESTVIK, AB ^{[1
]}

机构：

[1] ULLEVAL HOSP,DEPT CLIN CHEM,OSLO 1,NORWAY

来源：

THROMBOSIS RESEARCH | 1992年 / 66卷 / 01期

关键词：

CORONARY ARTERY DISEASE; INTRAVASCULAR COAGULATION; THROMBIN GENERATION; ANTICOAGULATION; WARFARIN;

D O I：

10.1016/0049-3848(92)90155-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sixty-four patients undergoing aorto-coronary bypass surgery were randomized to receive antithrombotic treatment with acetylsalicylic acid (ASA), 300 mg/d (n = 30) or warfarin, INR = 2.5 4.2 (n = 34 ). The levels of fibrinogen, thrombin - antithrombin III complexes (TAT), fibrinopeptide A (FPA) and D-dimer were assessed before surgery and 9 months postoperatively. In the warfarin treated group the fibrinogen levels were increased after 9 months, while the levels of TAT, FPA and D-dimer were decreased. In the ASA group TAT levels were increased at 9 months, whereas no significant changes in fibrinogen, FPA or D-dimer from baseline were noted. Thus, a reduced activation of the coagulation system has been demonstrated during long-term treatment with warfarin in patients with coronary artery disease.

引用

页码：55 / 60

页数：6

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