THE SYNTHESIS OF IL-1 RECEPTOR ANTAGONIST (IL-1RA) BY SYNOVIAL FIBROBLASTS IS MARKEDLY INCREASED BY THE CYTOKINES TNF-ALPHA AND IL-1

被引：35

作者：

MARTELPELLETIER, J

MCCOLLUM, R

PELLETIER, JP

机构：

[1] Rheumatic Disease Unit, Notre-Dame Hospital Research Center, Montreal, Que.

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1175卷 / 03期

关键词：

IL-1RA; CYTOKINE; GROWTH FACTOR; SYNOVIAL FIBROBLAST; RECEPTOR ANTAGONIST;

D O I：

10.1016/0167-4889(93)90221-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of inhibitors which block the action of IL-1 has significant implications in the control of inflammation. Different modulators of cellular metabolism were studied for their effect on the synthesis of IL-1 receptor antagonist (IL-1ra). Among the different growth factors and cytokines studied, only the inflammatory mediators IL-1 and TNF-alpha and one growth factor, PDGF-BB, were found to significantly increase, in an additive manner, the synthesis and secretion of IL-1ra.

引用

页码：302 / 305

页数：4

共 14 条

[1]

AREND WP, 1991, J IMMUNOL, V147, P1530

[2] BIOLOGICAL PROPERTIES OF RECOMBINANT HUMAN MONOCYTE-DERIVED INTERLEUKIN-1 RECEPTOR ANTAGONIST [J].