TRANSFER OF INSULIN-DEPENDENT DIABETES BETWEEN HLA-IDENTICAL SIBLINGS BY BONE-MARROW TRANSPLANTATION

被引：167

作者：

LAMPETER, EF

HOMBERG, M

QUABECK, K

SCHAEFER, UW

WERNET, P

BERTRAMS, J

GROSSEWILDE, H

GRIES, FA

KOLB, H

机构：

[1] UNIV ESSEN GESAMTHSCH,DEPT BONE MARROW TRANSPLANT,W-4300 ESSEN 1,GERMANY

[2] UNIV DUSSELDORF,INST HAEMOSTASIS & BLOOD TRANSFUS,W-4000 DUSSELDORF 1,GERMANY

[3] UNIV ESSEN GESAMTHSCH,INST IMMUNOL,W-4300 ESSEN 1,GERMANY

[4] ELISABETH HOSP,DEPT LAB MED,ESSEN,GERMANY

来源：

LANCET | 1993年 / 341卷 / 8855期

关键词：

D O I：

10.1016/0140-6736(93)91148-F

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-dependent diabetes was observed in a woman, aged 29, 4 years after transplantation of bone marrow from her HLA-identical brother with insulin-dependent diabetes. Both had classic symptoms and insulin dependency from onset. At diagnosis of diabetes the recipient was positive for high-titre islet cell antibodies (ICA) whereas she had been ICA negative before transplantation. Chromosomal analyses verified that all circulating leucocytes were of male donor type. These findings suggest transfer of insulin-dependent diabetes by bone marrow cells and confirm the immune nature of the disease.

引用

页码：1243 / 1244

页数：2

共 10 条

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