GLUTATHIONE METABOLISM IN HEART AND LIVER OF THE AGING RAT

被引：46

作者：

STIO, M ^{[1
]}

IANTOMASI, T ^{[1
]}

FAVILLI, F ^{[1
]}

MARRACCINI, P ^{[1
]}

LUNGHI, B ^{[1
]}

VINCENZINI, MT ^{[1
]}

TREVES, C ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT BIOCHEM SCI,I-50134 FLORENCE,ITALY

来源：

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 1994年 / 72卷 / 1-2期

关键词：

GLUTATHIONE METABOLISM; AGE; RAT HEART; RAT LIVER;

D O I：

10.1139/o94-010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comprehensive study on glutathione metabolism in rat heart and liver as a function of age was performed. In the heart, reduced glutathione, total glutathione, and the glutathione redox index showed a decrease during aging, while oxidized glutathione levels increased in 5-month-old rats with respect to the young animals and remained quite constant in 14- and 27-month-old rats. In the liver, the highest levels of reduced glutathione were found in the 2-month-old rats, while oxidized glutathione reached a peak at 5 months. Glutathione-associated enzymes showed age-related changes. Glutathione peroxidase, unaffected by aging in the heart, decreased in the liver of the 27-month-old rats. In the heart and the Liver, the highest values of glutathione 5-transferase were found at 5 months and 27 months, respectively. Glucose-6-phosphate dehydrogenase followed a similar trend in both heart and liver. Glutathione reductase also showed the same behaviour in heart and in liver, increasing in old rats with respect to the other age groups. A decrease in gamma-glutamylcysteine synthetase was found in the heart and liver of 27-month-old rats in comparison with the 2-month-old ones. In conclusion, a decreased antioxidant capability has been demonstrated in both heart and liver of old rats.

引用

页码：58 / 61

页数：4

共 30 条

[1] INFLUENCE OF AGING AND DRUG-TREATMENT ON THE CEREBRAL GLUTATHIONE SYSTEM [J].