PHYSICOCHEMICAL CHARACTERIZATION OF A NEW RESPIRABLE FORM OF NEDOCROMIL

被引：21

作者：

CHAN, HK ^{[1
]}

GONDA, I ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT PHARM,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1995年 / 84卷 / 06期

关键词：

D O I：

10.1002/jps.2600840606

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Elongated, respirable particles of nedocromil were prepared by its crystallization from N-methyl-2-pyrrolidone (NMP) obtained from an aqueous solution of its sodium salt by precipitation with hydrochloric acid. Aerosols of these particles were recently generated and characterized for their aerodynamic properties (Chan, H.-K.; Gonda, I. J. Aerosol Med. 1993, 6, 241-249). This paper reports the physicochemical properties of the solid form of nedocromil as characterized by polarizing optical and scanning electron microscopies, thermal analysis (DSC, TGA), X-ray powder diffraction, water vapor adsorption isotherms, mass spectrometry, solid state Fourier transform IR and solution H-1-NMR spectroscopies.

引用

页码：692 / 696

页数：5

共 13 条

[1] PHARMACEUTICAL IMPLICATIONS OF PARTICLE GROWTH AT HIGH RELATIVE HUMIDITIES [J].