INTERACTION OF THE P53-REGULATED PROTEIN GADD45 WITH PROLIFERATING CELL NUCLEAR ANTIGEN

被引：916

作者：

SMITH, ML

CHEN, IT

ZHAN, QM

BAE, IS

CHEN, CY

GILMER, TM

KASTAN, MB

OCONNOR, PM

FORNACE, AJ

机构：

[1] NCI, DEV THERAPEUT PROGRAM, MOLEC PHARMACOL LAB, BETHESDA, MD 20892 USA

[2] JOHNS HOPKINS UNIV, CTR ONCOL, BALTIMORE, MD 21287 USA

[3] GLAXO INC, RES INST, RES TRIANGLE PK, NC 27709 USA

来源：

SCIENCE | 1994年 / 266卷 / 5189期

关键词：

D O I：

10.1126/science.7973727

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21(WAF1/CIP1), whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.

引用

页码：1376 / 1380

页数：5

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