LONGICIN AND GONIOTHALAMICINONE - NOVEL BIOACTIVE MONOTETRAHYDROFURAN ACETOGENINS FROM ASIMINA-LONGIFOLIA

被引：23

作者：

YE, Q

ZENG, L

ZHANG, Y

ZHAO, GX

MCLAUGHLIN, JL

WOO, MH

EVERT, DR

机构：

[1] PURDUE UNIV,SCH PHARM & PHARM SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

[2] TAEGO HYOSUMG CATHOLIC UNIV,COLL PHARM,DEPT PHARM,KYONG SAN 713702,SOUTH KOREA

[3] UNIV GEORGIA,GEORGIA AGR EXPT STN,DEPT HORT,TIFTON,GA 31793

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 09期

关键词：

D O I：

10.1021/np50123a010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Longicin [1] and (2,4-cis and trans)-goniothalamicinone [2], two new monotetrahydrofuran Annonaceous acetogenins, have been isolated from the leaves and twigs of Asimina longifolia (the long leaf paw paw) by the use of the brine shrimp lethality test for bioactivity-directed fractionation. The structures were elucidated based on spectroscopic and chemical methods. Compound 1 was converted to its ketolactone isomer, (2,4-cis and trans)longicinone [3], to aid the stereochemical elucidation of 1. Compounds 1-3 showed selective and potent cytotoxicities to certain human tumor cell lines, with the potency of 1 against pancreatic carcinoma (PaCa-2) over one million rimes that of adriamycin. Nine known cytotoxic acetogenins, annonacin, xylomaticin, isoannonacin, gigantetrocins A and B, muricatetrocins A and B, gigantetrocin-A-one and goniothalamicin, were also isolated for the first time from this species.

引用

页码：1398 / 1406

页数：9

共 25 条

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