A ROLE FOR HIPPOCAMPAL OPIOIDS IN LONG-TERM FUNCTIONAL PLASTICITY

被引：70

作者：

MORRIS, BJ

JOHNSTON, HM

机构：

[1] B.J. Morris and H.M. Johnston are, the Dept of Pharmacology, The University of Glasgow, Glasgow, G12 8QQ, West Medical Building

来源：

TRENDS IN NEUROSCIENCES | 1995年 / 18卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0166-2236(95)93927-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the granule cells of the hippocampus, glutamate coexists with opioid peptides derived from the proenkephalin and prodynorphin genes. The functional significance of this coexistence has been unclear but recent evidence suggests that the dynorphins and enkephalins play a crucial role in regulating the efficiency of neurotransmission at granule-cell synapses. Together with evidence that the lever of opioid activity in this pathway can change dramatically according to the physiological or pathological state of the tissue, this information focusses attention on granule-cell opioids as primary mediators of hippocampal plasticity.

引用

页码：350 / 355

页数：6

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