AGING AND UNUSUAL CATECHOLAMINE-CONTAINING STRUCTURES IN THE MOUSE-BRAIN

被引：30

作者：

MASUOKA, DT

JONSSON, G

FINCH, CE

机构：

[1] UNIV CALIF IRVINE,IRVINE,CA 92664

[2] KAROLINSKA INST,DEPT HISTOL,S-10401 STOCKHOLM 60,SWEDEN

[3] UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR,LOS ANGELES,CA 90007

[4] UNIV SO CALIF,DEPT MOLEC BIOL,LOS ANGELES,CA 90007

来源：

BRAIN RESEARCH | 1979年 / 169卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-8993(79)91034-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brains of C57BL/6J mice, aged 4, 8 and 20-29 months, were examined by the Falck-Hillarp histochemical fluorescence technique. Numerous large, intensely fluorescent green to yellow-green spots (LIFS) were observed in the brains of senescent mice. LIFS were generally round to ovoid in shape and ranged in size from about 10 μm to about 30 μm. Histochemical and pharmacological procedures and spectral analysis indicated that the formaldehyde-induced fluorescence of the LIFS was due to the presence of catecholamines (CA) rather than aging pigment. Their distribution in the brain suggests an association with nerve axons or terminals rather than cell bodies. The number of LIFS in the hypothalamus increased progressively during aging. It is proposed that LIFS may represent age-related, unusual CA accumulation in enlargements proximal to axonal or terminal portions undergoing spontaneous degeneration. © 1979.

引用

页码：335 / 341

页数：7