TERATOGENIC ACTIVITY OF A THALIDOMIDE ANALOGOUS EM12 IN RATS ON A LOW-ZINC DIET

被引：27

作者：

JACKSON, AJ ^{[1
]}

SCHUMACHER, HJ ^{[1
]}

机构：

[1] UNIV CINCINNATI,DEPT ENVIRONM HLTH,CINCINNATI,OH 45229

来源：

TERATOLOGY | 1979年 / 19卷 / 03期

关键词：

D O I：

10.1002/tera.1420190310

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The relationship between the teratogenicity of EM12, 2‐(2,6‐dioxopiperiden‐3′‐yl) phthalimidine, a stable analogue of thalidomide, and zinc status in the maternal animal was investigated using pregnant rats on a low‐zinc diet (1 ppm zinc, days 0–14 gestation) as the experimental model. Previous studies with this compound in rats fed a commercial diet at oral doses up to 250 mg/kg per day for three days and intravenous doses up to 10 mg/kg per day for three days failed to produce “typical” thalidomide malformations. However, when a dose of 150 mg/kg was given intraperitoneally to rats on a low‐zinc diet, typical thalidomide malformations occurred with an incidence of 57.5%. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：341 / 344

页数：4

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