SYNTHESIS OF PHTHALTHRIN-14C (NEO-PYNAMIN-14C)

Phthalthrin labelled with 14C in the alcoholic moiety was synthesized via an intermediate ∆1-tetrahydrophthalic anhydride-14C. A preparative pathway leading to the intermediate was investigated in order to shorten the synthetic steps. Thus the intermediate was prepared in two steps starting with potassium cyanide-14C. Position of double bond introduced into the molecule was confirmed from IR spectrum and melting point. Chemical and radiochemical purities of intermediates and the final product were ascertained on scanning the radio-thin-layer chromatograms. A brief description on the self-decomposition of phthalthrin-14C and an intermediate is also given. © 1969 Taylor and Francis Group LLC.