PERCUTANEOUS-ABSORPTION IN EXPERIMENTAL EPIDERMAL DISEASE

被引：29

作者：

SOLOMON, AE

LOWE, NJ

机构：

[1] UNIV CALIF LOS ANGELES,DIV DERMATOL,LOS ANGELES,CA 90024

[2] SCRIPPS CLIN & RES FDN,DEPT DERMATOL,LA JOLLA,CA 92037

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1979年 / 100卷 / 06期

关键词：

D O I：

10.1111/j.1365-2133.1979.tb08078.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Little is known about the absorption of topical drugs in epidermal disease associated with epidermal proliferation and altered keratinization. An abnormal hairless mouse epidermis was produced by three different methods: ultraviolet light irradiation, topical vitamin A acid and topical acetic acid. An increased epidermal thickness resulted and the in vitro percutaneous absorption of 0.1% (4‐ 14C) hydrocortisone was found to be increased when compared with normal hairless mouse epidermis. This is evidence for defective skin barrier function in experimental epidermal disease. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：717 / 722

页数：6

共 16 条

[1] ROLE OF PROSTAGLANDIN-E, CYCLIC-AMP, AND CYCLIC-GMP IN PROLIFERATION OF GUINEA-PIG EAR SKIN STIMULATED BY TOPICAL APPLICATION OF VITAMIN-A ACID
ASO, K
RABINOWITZ, I
FARBER, EM
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1976, 67 (02) : 231 - 234
[2] COOPER MF, 1967, BRIT J DERMATOLOGY, V98, P230
[3] DETOMAS ME, 1963, BIOCHIM BIOPHYS ACTA, V70, P472
[4] ANIMAL-MODEL FOR SCREENING TOPICAL AND SYSTEMIC DRUGS FOR POTENTIAL USE IN TREATMENT OF PSORIASIS
DUVIVIER, A
STOUGHTON, RB
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1975, 65 (02) : 235 - 237
[5] ICHTHYOSIFORM DERMATOSES .3. STUDIES OF TRANSEPIDERMAL WATER LOSS
FROST, P
WEINSTEIN, GD
BOTHWELL, JW
WILDNAUER, R
[J]. ARCHIVES OF DERMATOLOGY, 1968, 98 (03) : 230 - +
[6] SKIN WATER LOSS AND ACCIDENTAL HYPOTHERMIA IN PSORIASIS ICHTHYOSIS AND ERYTHRODERMA
GRICE, KA
BETTLEY, FR
[J]. BRITISH MEDICAL JOURNAL, 1967, 4 (5573) : 195 - &
[7] LYSOSOMES AND REACTIONS OF SKIN TO ULTRAVIOLET RADIATION
JOHNSON, BE
DANIELS, F
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1969, 53 (02) : 85 - +
[8] EFFECTS OF INTENSIVE APPLICATION OF RETINOIC ACID ON HUMAN SKIN
KAIDBEY, KH
KLIGMAN, AM
YOSHIDA, H
[J]. BRITISH JOURNAL OF DERMATOLOGY, 1975, 92 (06) : 693 - 701
[9] ESSENTIAL FATTY-ACID DEFICIENT HAIRLESS MOUSE - MODEL OF CHRONIC EPIDERMAL HYPER-PROLIFERATION
LOWE, NJ
STOUGHTON, RB
[J]. BRITISH JOURNAL OF DERMATOLOGY, 1977, 96 (02) : 155 - 162
[10] STUDIES ON THE PERCUTANEOUS ABSORPTION OF C-14 LABELED STEROIDS BY USE OF THE GAS-FLOW CELL
MALKINSON, FD
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1958, 31 (01) : 19 - 28

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