SYNTHESIS OF POTENTIAL INHIBITORS OF THE ENZYME ASPARTATE TRANSCARBAMOYLASE

被引：31

作者：

LINDELL, SD

TURNER, RM

机构：

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(00)98077-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two difluoromethylenephosphonates, 7 and 8, and the phosphinylmethylenephosphonate 9 were prepared as potential inhibitors of aspartate transcarbamoylase (ATCase). The synthesis of compound 8 was facilitated by development of a new direct method for converting nitroalkanes to alkanoic acids. Of the three phosphonates, the amide 27 proved to be a good inhibitor of mung bean ATCase (I50ñ 5μM). © 1990.

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页码：5381 / 5384

页数：4

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