EFFECTS OF SOME ANTI-ARRHYTHMIC AGENTS ON DOG HEART MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION

被引：8

作者：

ALTO, LE ^{[1
]}

DHALLA, NS ^{[1
]}

机构：

[1] UNIV MANITOBA,DEPT PHYSIOL,DIV EXPTL CARDIOL,WINNIPEG R3E 0W3,MANITOBA,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 3-4期

关键词：

Antiarrhythmic drugs; Canine myocardium; Mitochondrial oxidative phosphorylation;

D O I：

10.1016/0014-2999(79)90297-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Significant decreases in state 3 oxygen consumption, respiratory control index (RCI), ADP: O ratio and phosphorylation rate were observed in the presence of 0.1-1.0 mM quinidine; 0.5 mM or greater concentratiions elevated state 4 oxygen consumption. Lidocaine (1-2.5 mM) also depressed RCI and increased state 4 oxygen consumption but procaine amide (1-2.5 mM) was without effect. It is suggested that cardiodepressin by quinidine may be associated with its ability to impair mitochondrial metabolism. © 1979.

引用

页码：311 / 314

页数：4

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