PROGRESSIVE RENAL TOXICITY DUE TO IFOSFAMIDE

被引:38
作者
HENEY, D [1 ]
WHEELDON, J [1 ]
RUSHWORTH, P [1 ]
CHAPMAN, C [1 ]
LEWIS, IJ [1 ]
BAILEY, CC [1 ]
机构
[1] GEN INFIRM,DEPT CHEM PATHOL,LEEDS LS1 3EX,W YORKSHIRE,ENGLAND
关键词
D O I
10.1136/adc.66.8.966
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
A prospective and follow up study of renal tubular and glomerular function in 11 children receiving ifosfamide treatment was conducted. Each child received between four and 14 courses of ifosfamide, given as a continuous infusion of 3 g/m2 over 24 hours for two or three days. Evidence of renal toxicity was seen in all patients. There was a treatment related rise in urinary tubular markers (N-acetyl-glucosaminidase and alpha-1 microglobulin). Recovery was limited, so that by the fourth course of treatment all values remained abnormal. There was an associated treatment related reduction in plasma phosphate concentration. Urinary albumin also showed a treatment related rise, but with fewer abnormal values. Electrophoresis was used to confirm tubular or glomerular patterns. Glomerular toxicity was less severe and occurred in fewer patients. The follow up study showed persistence of tubular damage in all seven patients examined, and there was evidence of glomerular damage in five of the seven children. Children receiving ifosfamide need to be carefully monitored for renal toxicity both during treatment and at follow up.
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收藏
页码:966 / 970
页数:5
相关论文
共 11 条
[1]  
CAZZOLA M, 1990, BLOOD, V75, P1903
[2]   URINARY ALBUMIN EXCRETION IN SCHOOL-CHILDREN [J].
DAVIES, AG ;
POSTLETHWAITE, RJ ;
PRICE, DA ;
BURN, JL ;
HOULTON, CA ;
FIELDING, BA .
ARCHIVES OF DISEASE IN CHILDHOOD, 1984, 59 (07) :625-630
[3]   TUBULAR NEPHROTOXICITY DURING LONG-TERM IFOSFAMIDE AND MESNA THERAPY [J].
GOREN, MP ;
PRATT, CB ;
VIAR, MJ .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1989, 25 (01) :70-72
[4]  
HENEY D, 1989, LANCET, V2, P103
[5]   ANALYSIS OF PROTEINURIA USING A COMMERCIAL SYSTEM FOR AUTOMATED ELECTROPHORESIS AND ISOELECTRIC-FOCUSING [J].
JACKSON, PJ ;
SAMPSON, CJ ;
COOPER, EH ;
HENEY, D ;
BROCKLEBANK, JT .
ANNALS OF CLINICAL BIOCHEMISTRY, 1988, 25 :319-324
[6]  
KUNIN CM, 1978, PEDIATRICS, V62, P751
[7]   URINARY-EXCRETION OF N-ACETYL-BETA-D-GLUCOSAMINIDASE IN CHILDREN [J].
OSBORNE, J .
ARCHIVES OF DISEASE IN CHILDHOOD, 1980, 55 (09) :719-721
[8]   IFOSFAMIDE IN PEDIATRIC ONCOLOGY - TRIED BUT NOT TESTED [J].
SHAW, PJ ;
EDEN, T .
LANCET, 1990, 335 (8696) :1022-1023
[9]   HYPOPHOSPHATEMIC RICKETS AFTER IFOSFAMIDE TREATMENT IN CHILDREN [J].
SKINNER, R ;
PEARSON, ADJ ;
PRICE, L ;
CUNNINGHAM, K ;
CRAFT, AW .
BRITISH MEDICAL JOURNAL, 1989, 298 (6687) :1560-1561
[10]   NEPHROTOXICITY AFTER IFOSFAMIDE [J].
SKINNER, R ;
PEARSON, ADJ ;
PRICE, L ;
COULTHARD, MG ;
CRAFT, AW .
ARCHIVES OF DISEASE IN CHILDHOOD, 1990, 65 (07) :732-738