A PROTEIN OF THE ENDOPLASMIC-RETICULUM INVOLVED EARLY IN POLYPEPTIDE TRANSLOCATION

被引：263

作者：

GORLICH, D

HARTMANN, E

PREHN, S

RAPOPORT, TA

机构：

[1] MAX DELBRUCK CTR MOLEC MED, ROBERT ROSSLE STR 10, O-1115 BERLIN, GERMANY

[2] HUMBOLDT UNIV, INST BIOCHEM, O-1040 BERLIN, GERMANY

来源：

NATURE | 1992年 / 357卷 / 6373期

关键词：

D O I：

10.1038/357047a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.

引用

页码：47 / 52

页数：6

共 31 条

[1] A YEAST MITOCHONDRIAL OUTER-MEMBRANE PROTEIN ESSENTIAL FOR PROTEIN IMPORT AND CELL VIABILITY
BAKER, KP
SCHANIEL, A
VESTWEBER, D
SCHATZ, G
[J]. NATURE, 1990, 348 (6302) : 605 - 609
[2] THE SIGNAL RECOGNITION PARTICLE RECEPTOR MEDIATES THE GTP-DEPENDENT DISPLACEMENT OF SRP FROM THE SIGNAL SEQUENCE OF THE NASCENT POLYPEPTIDE
CONNOLLY, T
GILMORE, R
[J]. CELL, 1989, 57 (04) : 599 - 610
[3] ASSEMBLY OF YEAST SEC PROTEINS INVOLVED IN TRANSLOCATION INTO THE ENDOPLASMIC-RETICULUM INTO A MEMBRANE-BOUND MULTISUBUNIT COMPLEX
DESHAIES, RJ
SANDERS, SL
FELDHEIM, DA
SCHEKMAN, R
[J]. NATURE, 1991, 349 (6312) : 806 - 808
[4] A YEAST MUTANT DEFECTIVE AT AN EARLY STAGE IN IMPORT OF SECRETORY PROTEIN PRECURSORS INTO THE ENDOPLASMIC-RETICULUM
DESHAIES, RJ
SCHEKMAN, R
[J]. JOURNAL OF CELL BIOLOGY, 1987, 105 (02) : 633 - 645
[5] PURIFICATION OF MICROSOMAL SIGNAL PEPTIDASE AS A COMPLEX
EVANS, EA
GILMORE, R
BLOBEL, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (03) : 581 - 585
[6] PROTEIN TRANSLOCATION ACROSS THE ENDOPLASMIC-RETICULUM .2. ISOLATION AND CHARACTERIZATION OF THE SIGNAL RECOGNITION PARTICLE RECEPTOR
GILMORE, R
WALTER, P
BLOBEL, G
[J]. JOURNAL OF CELL BIOLOGY, 1982, 95 (02) : 470 - 477
[7] THE SIGNAL SEQUENCE RECEPTOR HAS A 2ND SUBUNIT AND IS PART OF A TRANSLOCATION COMPLEX IN THE ENDOPLASMIC-RETICULUM AS PROBED BY BIFUNCTIONAL REAGENTS
GORLICH, D
PREHN, S
HARTMANN, E
HERZ, J
OTTO, A
KRAFT, R
WIEDMANN, M
KNESPEL, S
DOBBERSTEIN, B
RAPOPORT, TA
[J]. JOURNAL OF CELL BIOLOGY, 1990, 111 (06) : 2283 - 2294
[8] MUTANTS IN 3 NOVEL COMPLEMENTATION GROUPS INHIBIT MEMBRANE-PROTEIN INSERTION INTO AND SOLUBLE-PROTEIN TRANSLOCATION ACROSS THE ENDOPLASMIC-RETICULUM MEMBRANE OF SACCHAROMYCES-CEREVISIAE
GREEN, N
FANG, H
WALTER, P
[J]. JOURNAL OF CELL BIOLOGY, 1992, 116 (03) : 597 - 604
[9] THE SIGNAL RECOGNITION PARTICLE IN SACCHAROMYCES-CEREVISIAE
HANN, BC
WALTER, P
[J]. CELL, 1991, 67 (01) : 131 - 144
[10] A MEMBRANE COMPONENT OF THE ENDOPLASMIC-RETICULUM THAT MAY BE ESSENTIAL FOR PROTEIN TRANSLOCATION
HARTMANN, E
WIEDMANN, M
RAPOPORT, TA
[J]. EMBO JOURNAL, 1989, 8 (08) : 2225 - 2229

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