NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE

被引:2160
作者
ARRIAGADA, PV
GROWDON, JH
HEDLEYWHYTE, ET
HYMAN, BT
机构
[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,BOSTON,MA 02114
[2] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PATHOL,BOSTON,MA 02114
关键词
D O I
10.1212/WNL.42.3.631
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied the accumulation of neurofibrillary tangles (NFTs) and senile plaques (SPs) in 10 Alzheimer's disease patients who had been examined during life. We counted NFTs and SPs in 13 cytoarchitectural regions representing limbic, primary sensory, and association cortices, and in subcortical neurotransmitter-specific areas. The degree of neuropathologic change was compared with the severity of dementia, as assessed by the Blessed Dementia Scale and duration of illness. We found that (1) the severity of dementia was positively related to the number of NFTs in neocortex, but not to the degree of SP deposition; (2) NFTs accumulate in a consistent pattern reflecting hierarchic vulnerability of individual cytoarchitectural fields; (3) NFTs appeared in the entorhinal cortex, CA1/subiculum field of the hippocampal formation, and the amygdala early in the disease process; and (4) the degree of SP deposition was also related to a hierarchic vulnerability of certain brain areas to accumulate SPs, but the pattern of SP distribution was different from that of NFT.
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页码:631 / 639
页数:9
相关论文
共 42 条
[1]  
Alzheimer A., 1907, ALLG Z PSYCHIATR PS, V64, P146, DOI DOI 10.1002/CA.980080612
[2]   The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease [J].
Arnold, Steven E. ;
Hyman, Bradley T. ;
Flory, Jill ;
Damasio, Antonio R. ;
Van Hoesen, Gary W. .
CEREBRAL CORTEX, 1991, 1 (01) :103-116
[3]  
ARRIAGADA P, 1990, J NEUROPATHOL EXP NE, V49, P226
[4]  
ARRIAGADA PV, 1990, NEUROBIOL AGING, V11, P324
[5]   TOPOGRAPHIC DISTRIBUTION OF NEUROFIBRILLARY TANGLES AND GRANULOVACUOLAR DEGENERATION IN HIPPOCAMPAL CORTEX OF AGING AND DEMENTED PATIENTS - QUANTITATIVE STUDY [J].
BALL, MJ .
ACTA NEUROPATHOLOGICA, 1978, 42 (02) :73-80
[6]   ASSOCIATION BETWEEN QUANTITATIVE MEASURES OF DEMENTIA AND OF SENILE CHANGE IN CEREBRAL GREY MATTER OF ELDERLY SUBJECTS [J].
BLESSED, G ;
TOMLINSON, BE ;
ROTH, M .
BRITISH JOURNAL OF PSYCHIATRY, 1968, 114 (512) :797-+
[7]  
Blocq P, 1892, SEM MED, V12, P445
[8]   REGIONAL PATTERN OF DEGENERATION IN ALZHEIMERS-DISEASE - NEURONAL LOSS AND HISTOPATHOLOGICAL GRADING [J].
BRUN, A ;
ENGLUND, E .
HISTOPATHOLOGY, 1981, 5 (05) :549-564
[9]   DISTRIBUTION OF CEREBRAL DEGENERATION IN ALZHEIMERS-DISEASE - CLINICOPATHOLOGICAL STUDY [J].
BRUN, A ;
GUSTAFSON, L .
ARCHIV FUR PSYCHIATRIE UND NERVENKRANKHEITEN, 1976, 223 (01) :15-33
[10]   CLINICOPATHOLOGIC STUDIES IN DEMENTIA - NONDEMENTED SUBJECTS WITH PATHOLOGICALLY CONFIRMED ALZHEIMERS-DISEASE [J].
CRYSTAL, H ;
DICKSON, D ;
FULD, P ;
MASUR, D ;
SCOTT, R ;
MEHLER, M ;
MASDEU, J ;
KAWAS, C ;
ARONSON, M ;
WOLFSON, L .
NEUROLOGY, 1988, 38 (11) :1682-1687