SELECTIVE ELIMINATION OF HIV-1-INFECTED CELLS WITH AN INTERLEUKIN-2 RECEPTOR SPECIFIC CYTOTOXIN

被引：48

作者：

FINBERG, RW

WAHL, SM

ALLEN, JB

SOMAN, G

STROM, TB

MURPHY, JR

NICHOLS, JC

机构：

[1] SERAGEN,HOPKINTON,MA 01748

[2] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

[3] NIDR,IMMUNOL LAB,BETHESDA,MD 20892

[4] BETH ISRAEL HOSP,CHARLES A DANA RES INST,BOSTON,MA 02215

[5] HARVARD UNIV,BETH ISRAEL HOSP,THORNDIKE LAB,BOSTON,MA 02215

[6] BETH ISRAEL HOSP,DEPT MED,BOSTON,MA 02215

[7] BOSTON UNIV MED,BOSTON UNIV HOSP,BOSTON,MA 02118

来源：

SCIENCE | 1991年 / 252卷 / 5013期

关键词：

D O I：

10.1126/science.1904628

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infection by human immunodeficiency virus type 1 (HIV-1) is associated with cellular activation and expression of the interleukin-2 (IL-2) receptor. A genetically engineered fusion toxin, DAB486 IL-2, that contains the enzymatic site and translocation domain of diphtheria toxin and the receptor binding domain of IL-2 specifically kills cells that express high-affinity IL-2 receptors. This toxin selectively eliminated the HIV-1-infected cells from mixed cultures of infected and uninfected cells and inhibited production of viral proteins and infectious virus. Thus, cellular activation antigens present a target for early antiviral intervention.

引用

页码：1703 / 1705

页数：3

共 28 条

[1] EXPRESSION OF INTERLEUKIN-2 RECEPTORS BY MONOCYTES FROM PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME AND INDUCTION OF MONOCYTE INTERLEUKIN-2 RECEPTORS BY HUMAN IMMUNODEFICIENCY VIRUS INVITRO [J].