STRUCTURAL DETERMINATION OF GANGLIOSIDES THAT BIND TO INFLUENZA-A, INFLUENZA-B, AND INFLUENZA-C VIRUSES BY AN IMPROVED BINDING ASSAY - STRAIN-SPECIFIC RECEPTOR EPITOPES IN SIALO-SUGAR CHAINS

被引:123
作者
SUZUKI, Y
NAKAO, T
ITO, T
WATANABE, N
TODA, Y
XU, GY
SUZUKI, T
KOBAYASHI, T
KIMURA, Y
YAMADA, A
SUGAWARA, K
NISHIMURA, H
KITAME, F
NAKAMURA, K
DEYA, E
KISO, M
HASEGAWA, A
机构
[1] FUKUI MED SCH,DEPT BIOCHEM,FUKUI 91011,JAPAN
[2] KYOTO PREFECTURAL UNIV MED,DEPT MICROBIOL,KYOTO 602,JAPAN
[3] YAMAGATA UNIV,SCH MED,DEPT BACTERIOL,YAMAGATA 99023,JAPAN
[4] SNOW BLAND MILK PROD CO LTD,KAWAGOE 350,JAPAN
[5] GIFU UNIV,DEPT APPL BIOORGAN CHEM,GIFU 50111,JAPAN
关键词
D O I
10.1016/0042-6822(92)90687-K
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
An improved binding assay for detection of ganglioside receptors for influenza A, B, and C viruses was developed. In this system, the virions bound to gangliosides that were developed on a silica gel thin-layer plate were detected by mouse monoclonal antibody against viral hemagglutinin and peroxidase-conjugated anti-mouse immunoglobrin. No hydrolysis of the gangliosides by viral receptor-destroying enzyme was detected in the present condition. The reactivity of the viruses to gangliosides depended on the amount of developed gangliosides (10 pmols-10 nmols), the molecular species of sialic acid, and their sugar sequences. Human influenza A (PR/8/34), B (Lee/40), and C (Ann Arbor/1/50) viruses bound different receptor epitopes of sialo-sugar chains of gangliosides. The A/PR/8 virus bound most effectively to Neu5Ac-containing lacto-series gangliosides carrying type I and type II sugar chains, followed by ganglio-series and hematoside-series gangliosides. The A/PR/8 virus weakly bound to Neu5Ac α2,6lactotetraosylceramide [IV6(Neu5Ac)Lc4Cer] and Neu5Ac α2,6paragloboside [IV6(Neu5Ac)nLc4Cer] carrying Neu5Ac α2,6Gal sequence, although thoir Neu5Ac α2,3Gal derivatives were the most potent gangliosides tested. B/Lee/40 bound restrictively to IV6(Neu5Ac)Lc4Cer and IV6(Neu5Ac)nLc4Cer, which carry Neu5Ac α2,6Gal sequence, and type I and type II lacto-series sugar chain, respectively. C/Ann Arbor/1/50 reacted only with 9-O-Ac-Neu5Ac-carrying sugar chains in all the gangliosides tested. This method also allowed the microanalysis of receptor gangliosides of unknown samples. ESK cells, sensitive to the influenza A viruses infection, expressed several kinds of receptor active gangliosides, while those from ESK-R cells, resistant to the virus infection, were undetectable. © 1992.
引用
收藏
页码:121 / 131
页数:11
相关论文
共 46 条
  • [1] Air G M, 1987, Contrib Microbiol Immunol, V8, P20
  • [2] ISOLATION AND CHARACTERIZATION OF GANGLIOSIDE 9-O-ACETYL-GD3 FROM BOVINE BUTTERMILK
    BONAFEDE, DM
    MACALA, LJ
    CONSTANTINEPATON, M
    YU, RK
    [J]. LIPIDS, 1989, 24 (08) : 680 - 684
  • [3] DANIELS RS, 1983, VIROLOGY, V138, P174
  • [4] GASA S, 1983, J BIOL CHEM, V258, P876
  • [5] A NOVEL-APPROACH TO THE STUDY OF GLYCOLIPID RECEPTORS FOR VIRUSES - BINDING OF SENDAI VIRUS TO THIN-LAYER CHROMATOGRAMS
    HANSSON, GC
    KARLSSON, KA
    LARSON, G
    STROMBERG, N
    THURIN, J
    ORVELL, C
    NORRBY, E
    [J]. FEBS LETTERS, 1984, 170 (01) : 15 - 18
  • [6] SYNTHETIC STUDIES ON SIALOGLYCOCONJUGATES .23. TOTAL SYNTHESIS OF SIALYL-ALPHA(2-]6)-LACTOTETRAOSYLCERAMIDE AND SIALYL-ALPHA(2-]6)-NEOLACTOTETRAOSYLCERAMIDE
    HASEGAWA, A
    HOTTA, K
    KAMEYAMA, A
    ISHIDA, H
    KISO, M
    [J]. JOURNAL OF CARBOHYDRATE CHEMISTRY, 1991, 10 (03) : 439 - 459
  • [7] THE SURFACE-RECEPTOR IS A MAJOR DETERMINANT OF THE CELL TROPISM OF INFLUENZA-C VIRUS
    HERRLER, G
    KLENK, HD
    [J]. VIROLOGY, 1987, 159 (01) : 102 - 108
  • [8] THE RECEPTOR-DESTROYING ENZYME OF INFLUENZA-C VIRUS IS NEURAMINATE-O-ACETYLESTERASE
    HERRLER, G
    ROTT, R
    KLENK, HD
    MULLER, HP
    SHUKLA, AK
    SCHAUER, R
    [J]. EMBO JOURNAL, 1985, 4 (06) : 1503 - 1506
  • [9] SENSITIVE ENZYME-IMMUNOSTAINING AND DENSITOMETRIC DETERMINATION ON THIN-LAYER CHROMATOGRAPHY OF N-GLYCOLYLNEURAMINIC ACID-CONTAINING GLYCOSPHINGOLIPIDS, HANGANUTZIU-DEICHER ANTIGENS
    HIGASHI, H
    FUKUI, Y
    UEDA, S
    KATO, S
    HIRABAYASHI, Y
    MATSUMOTO, M
    NAIKI, M
    [J]. JOURNAL OF BIOCHEMISTRY, 1984, 95 (05) : 1517 - 1520
  • [10] IMPROVED METHOD FOR LARGE-SCALE PURIFICATION OF BRAIN GANGLIOSIDES BY Q-SEPHAROSE COLUMN CHROMATOGRAPHY - IMMUNOCHEMICAL DETECTION OF C-SERIES POLYSIALOGANGLIOSIDES IN ADULT BOVINE BRAINS
    HIRABAYASHI, Y
    NAKAO, T
    MATSUMOTO, M
    OBATA, K
    ANDO, S
    [J]. JOURNAL OF CHROMATOGRAPHY, 1988, 445 (02): : 377 - 384