IONIC SELECTIVITY OF VOLUME-SENSITIVE CURRENTS IN HUMAN EPITHELIAL-CELLS

被引：46

作者：

RASOLA, A

GALIETTA, LJV

GRUENERT, DC

ROMEO, G

机构：

[1] IST GIANNINA GASLINI,GENET MOLEC LAB,I-16148 GENOA,ITALY

[2] UNIV CALIF SAN FRANCISCO,CARDIOVASC & CANC RES INST,DEPT LAB MED,SAN FRANCISCO,CA 94143

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1139卷 / 04期

关键词：

CHLORIDE CURRENT; CELL VOLUME; P-GLYCOPROTEIN; EPITHELIAL CELLS; PATCH-CLAMP;

D O I：

10.1016/0925-4439(92)90108-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ion selectivity of swelling-activated Cl- currents has been investigated in three different human epithelial cell lines, two derived from the airway epithelium (9HTEo- and CFNPE9o-) and one from a colon carcinoma (T84). The relative permeability of volume-sensitive currents with respect to Cl- is: I- (1.19) > NO3- (1.07) almost-equal-to Br-(1.05) > Cl-(1.0) > F-(0.5) almost-equal-to HCO3-(0.48) > isethionate(0.28) > aspartate (0.14) almost-equal-to gluconate(0.13) almost-equal-to SO42-(0.12). This type of ion selectivity is similar to that described for depolarization-activated outwardly rectifying Cl- channels found in epithelial cells.

引用

页码：319 / 323

页数：5

共 23 条

[1] DEMONSTRATION THAT CFTR IS A CHLORIDE CHANNEL BY ALTERATION OF ITS ANION SELECTIVITY [J].