INCREASED LEVELS OF IGA ANTIBODIES TO CYTOKERATIN-18 AND EPIDERMAL KERATIN IN RHEUMATOID-ARTHRITIS

被引：16

作者：

BORG, AA

DAWES, PT

MATTEY, DL

机构：

[1] Staffordshire Rheumatology Centre, Stoke-On-Trent

来源：

ARTHRITIS AND RHEUMATISM | 1993年 / 36卷 / 02期

关键词：

D O I：

10.1002/art.1780360214

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To investigate whether levels of antibodies to cytokeratin-18 (CK-18) and epidermal keratin (EPK) were raised in patients with rheumatoid arthritis (RA). Methods. We measured antibodies to CK-18 and EPK in patients with RA and in patients with osteoarthritis (OA), as well as in normal control subjects by means of an enzyme-linked immunosorbent assay. Results. IgA antibodies to both CK-18 and EPK were significantly increased in patients with RA compared with the controls and with patients with OA (P < 0.0001). No difference was noted in the levels of IgG or IgM antibodies to CK-18 or EPK between controls and patients with OA or RA. Conclusion. Raised levels of IgA autoantibody to CK-18 and EPK may reflect damage to cytokeratin-containing cells (e.g., in synovial endothelium) and could be a useful disease marker in RA.

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页码：229 / 233

页数：5

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