INDEPENDENCE OF SALT INTAKE INDUCED BY CALCIUM DEPRIVATION FROM THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

被引:15
作者
TORDOFF, MG
PILCHAK, DM
HUGHES, RL
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 264卷 / 03期
关键词
SODIUM; SODIUM BALANCE; BLOOD PRESSURE; SPIRONOLACTONE; LOSARTAN; DUP-753; RATS;
D O I
10.1152/ajpregu.1993.264.3.R492
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We investigated whether the elevated NaCl intake shown by calcium-deprived rats is mediated by the renin-angiotensin-aldosterone system. First, we looked for manifestations of altered renin-angiotensin-aldosterone system activity during the progression of calcium deficiency. There were no differences between control and calcium-deprived rats in plasma aldosterone concentrations, plasma renin activity, plasma sodium concentrations, sodium balance, or blood pressure. Second, we used selective pharmacological antagonists to examine whether disruption of the renin-aldosterone-angiotensin system influenced salt intake. Blockade of aldosterone receptors with spironolactone (25 mg . kg-1 . day-1 sc for 7 days) had no effect on NaCl intake of control or calcium-deprived rats. Angiotensin AT1 receptor blockade with losartan potassium (0.5-10 mg/kg orally) had no effect on NaCl intake of control or calcium-deprived rats but doses >0.5 mg/kg decreased NaCl intake of adrenalectomized rats. Taken together, these findings indicate that the renin-angiotensin-aldosterone system does not mediate the increased NaCl intake produced by calcium deficiency. The appetite for salt produced by calcium deficiency involves a different physiological substrate from most other models of NaCl intake.
引用
收藏
页码:R492 / R499
页数:8
相关论文
共 31 条
[1]  
BEAUCHAMP GK, 1991, CHEM SENSES, V4, P85
[2]   EFFECT OF SPIRONOLACTONE ON ELECTROLYTES, RENIN, ACTH AND CORTICOSTEROIDS IN THE RAT [J].
CHABERT, PR ;
GUELPADECORZANT, C ;
RIONDEL, AM ;
VALLOTTON, MB .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1984, 20 (6A) :1253-1259
[3]   SEX AND SODIUM-INTAKE IN THE RAT [J].
CHOW, SY ;
SAKAI, RR ;
WITCHER, JA ;
ADLER, NT ;
EPSTEIN, AN .
BEHAVIORAL NEUROSCIENCE, 1992, 106 (01) :172-180
[4]   PLASMA ANGIOTENSIN-II - INTERDEPENDENCE ON SODIUM AND CALCIUM HOMEOSTASIS [J].
DORIS, PA .
PEPTIDES, 1988, 9 (02) :243-248
[5]  
ERBLER HC, 1978, ALDOSTERONE ANTAGONI, P77
[6]   SODIUM APPETITE ELICITED BY INTRACEREBROVENTRICULAR INFUSION OF ANGIOTENSIN-II IN THE RAT .2. SYNERGISTIC INTERACTION WITH SYSTEMIC MINERALOCORTICOIDS [J].
FLUHARTY, SJ ;
EPSTEIN, AN .
BEHAVIORAL NEUROSCIENCE, 1983, 97 (05) :746-758
[7]   EFFECT OF MINERALOCORTICOIDS ON SPONTANEOUS SODIUM CHLORIDE APPETITE OF ADRENALECTOMIZED RATS [J].
FREGLY, MJ ;
WATERS, IW .
PHYSIOLOGY & BEHAVIOR, 1966, 1 (01) :65-&
[8]   ROLE OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN NACL APPETITE OF RATS [J].
FREGLY, MJ ;
ROWLAND, NE .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (01) :R1-R11
[9]  
FREGLY MJ, 1966, P SOC EXP BIOL MED, V123, P971
[10]   MINERAL BALANCE AND BLOOD-PRESSURE IN THE YOUNG SPONTANEOUSLY HYPERTENSIVE RAT [J].
JONES, MR ;
MARTINS, JE ;
CLEMENS, RA .
JOURNAL OF NUTRITION, 1988, 118 (01) :114-120