PROTON SPECTROSCOPY OF HUMAN STROKE - ASSESSMENT OF TRANSVERSE RELAXATION-TIMES AND PARTIAL VOLUME EFFECTS IN SINGLE VOLUME STEAM MRS

被引：20

作者：

BLAMIRE, AM ^{[1
]}

GRAHAM, GD ^{[1
]}

ROTHMAN, DL ^{[1
]}

PRICHARD, JW ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06510

来源：

MAGNETIC RESONANCE IMAGING | 1994年 / 12卷 / 08期

关键词：

STROKE; MAGNETIC RESONANCE; PROTON SPECTROSCOPY; PARTIAL VOLUME; TRANSVERSE RELAXATION TIME; LACTATE; N-ACETYL-ASPARTATE;

D O I：

10.1016/0730-725X(94)90087-8

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Proton T-2 relaxation times were measured in 13 stroke patients and 13 aged-matched normal subjects at 2.1 T. Spectra were acquired from an 8-cc volume using the STEAM sequence with echo times (TE) of 30.4 ms and 270.0 ms and repetition time of 2.8 s. Transverse relaxation times were estimated using two-point calculations. Percentage volume of infarct in the STEAM voxel was measured on spin-echo MRI encompassing the infarct and correlated with the peak amplitude of N-acetylated compounds (NA). T-2 values of NA, creatine, and choline resonances showed no significant difference between patients and controls. T-2 for lactate in patients was 780 +/- 257 ms, respectively (mean +/- SE, n = 7). In stroke patients, high inverse correlation was found between the absolute NA signal and partial volume of normal brain contributing to each spectrum (p < .001, r = 0.97). Together with unchanged T-2, this suggests that NAA largely disappears from infarcted tissue within 24 hr postinfarct.

引用

页码：1227 / 1235

页数：9

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