TRANSIENT RELEASE OF POTASSIUM MEDIATED BY ACTION OF SUBSTANCE-P ON RAT PAROTID SLICES

Substance P (a peptide of eleven amino acids) caused a Ca‐dependent release of K+ from rat parotid slices. The response to substance P differed from the alpha‐adrenergic and the cholinergic responses in that it was transient, of smaller extent, and was not inhibited by phentolamine and atropine. Substance P caused little, if any, amylase secretion. Successive additions of the peptide to the slice system maintained the effect of C+ release indicating that the transient response to a single addition of the peptide was due to inactivation of substance P and not due to a decline in the response of the tissue. © 1978 The Physiological Society