THE COMPARATIVE EFFECTS OF ISOPRINOSINE, LEVAMISOLE, MURAMYL DIPEPTIDE AND SM1213 ON LYMPHOCYTE AND MACROPHAGE PROLIFERATION AND ACTIVATION INVITRO

被引：91

作者：

HADDEN, JW ^{[1
]}

ENGLARD, A ^{[1
]}

SADLIK, JR ^{[1
]}

HADDEN, EM ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,IMMUNOPHARMACOL LAB,NEW YORK,NY 10021

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1979年 / 1卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0192-0561(79)90026-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Four immunopotentiators, levamisole, isoprinosine, muramyl dipeptide (MDP) and SM1213 were analysed in vitro on phytohemagglutinin-induced lymphocyte proliferation and lymphokine-induced macrophage proliferation and activation to kill Listeria monocytogenes. Levamisole and isoprinosine augmented all three functions. MDP and SM1213 induced macrophage activation directly. The effects of these agents on these cells at concentrations relevant to in vivo therapy supports their immunopharmacologic capacity to modify cellular immunity. © 1979.

引用

页码：17 / 27

页数：11

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