SUBGROUPS OF UTERINE LEIOMYOMAS BASED ON CYTOGENETIC ANALYSIS

被引:32
作者
HU, J
SURTI, U
机构
[1] UNIV PITTSBURGH, MAGEE WOMENS HOSP, DEPT PATHOL, FORBES AVE & HALKET ST, PITTSBURGH, PA 15213 USA
[2] UNIV PITTSBURGH, MAGEE WOMENS HOSP, DEPT HUMAN GENET, PITTSBURGH, PA 15213 USA
关键词
CYTOGENETIC SUBGROUPS; UTERINE LEIOMYOMAS;
D O I
10.1016/0046-8177(91)90009-E
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Chromosomes from 39 cases of benign uterine leiomyomas were studied. Consistent chromosomal abnormalities were detected in 15 cases (38.5%). Abnormalities involving chromosomes 12 and 14 with or without additional chromosomal changes were found in five cases (12.8%). Deletion of chromosome 7 was detected in five cases; in three cases (7.6%), this was the only abnormality present. Complex translocations involving X, 5, and 14 as well as X, 3, and 14 were observed in one case each. Insertion of a portion of chromosome 4 to chromosome 1, deletion involving chromosome 3, and nonreciprocal translocation between chromosomes 14 and 15 were observed in one case each. Monosomy 22, with a derived chromosome 14, was observed in one case. Trisomy 7 was also identified in one case. The structural and numeric abnormalities involved chromosomes X, 1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 14, 15, and 22. A normal 46,XX stem line with one or two abnormal cells was observed in 20 cases. Only normal karyotypes were obtained in the remaining four cases. A review of the literature and the results of our study indicate that uterine leiomyomas may be divided into eight groups based on cytogenetic analysis. © 1991.
引用
收藏
页码:1009 / 1016
页数:8
相关论文
共 32 条
[1]   NO AMPLIFICATION OR REARRANGEMENT OF INT1, GLI, OR COL2A1 IN UTERINE LEIOMYOMAS WITH T(12-14)(Q14-15-Q23-24) [J].
ARHEDEN, K ;
NILBERT, M ;
HEIM, S ;
MANDAHL, N ;
MITELMAN, F .
CANCER GENETICS AND CYTOGENETICS, 1989, 39 (02) :195-201
[2]   3 POSSIBLE CYTOGENETIC SUBGROUPS OF LEIOMYOSARCOMA [J].
BOGHOSIAN, L ;
DALCIN, P ;
TURCCAREL, C ;
RAO, U ;
KARAKOUSIS, C ;
SAIT, SJ ;
SANDBERG, AA .
CANCER GENETICS AND CYTOGENETICS, 1989, 43 (01) :39-49
[3]   AN INTERSTITIAL DELETION OF CHROMOSOME-7 MAY CHARACTERIZE A SUBGROUP OF UTERINE LEIOMYOMA [J].
BOGHOSIAN, L ;
DALCIN, P ;
SANDBERG, AA .
CANCER GENETICS AND CYTOGENETICS, 1988, 34 (02) :207-208
[4]  
CASARTELLI C, 1989, 3RD INT WORKSH CHROM
[5]  
COLLARD JG, 1987, CANCER RES, V47, P6666
[6]   CYTOGENETIC FINDINGS IN LEIOMYOSARCOMA OF THE SMALL BOWEL [J].
DALCIN, P ;
BOGHOSIAN, L ;
SANDBERG, AA .
CANCER GENETICS AND CYTOGENETICS, 1988, 30 (02) :285-288
[7]   CLONAL CHROMOSOME REARRANGEMENTS IN A UTERINE MYOMA [J].
GIBAS, Z ;
GRIFFIN, CA ;
EMANUEL, BS .
CANCER GENETICS AND CYTOGENETICS, 1988, 32 (01) :19-24
[8]  
Harnden DG, 1985, INT SYSTEM HUMAN CYT
[9]  
HARNDEN DG, 1985, BIRTH DEFECTS ORIG 1, V21
[10]   RECIPROCAL TRANSLOCATION T(3-12)(Q27-Q13) IN LIPOMA [J].
HEIM, S ;
MANDAHL, N ;
KRISTOFFERSSON, U ;
MITELMAN, F ;
ROOSER, B ;
RYDHOLM, A ;
WILLEN, H .
CANCER GENETICS AND CYTOGENETICS, 1986, 23 (04) :301-304