A NOVEL NON-ATAXIC GUINEA-PIG STRAIN WITH CEREBROCORTICAL AND CEREBELLAR ABNORMALITIES

被引：11

作者：

LEVRAM, V

VALSAMIS, M

MASLIAH, E

LEVINE, S

GODFREY, HP

机构：

[1] NEW YORK MED COLL, DEPT EXPTL PATHOL, BASIC SCI BLDG, VALHALLA, NY 10595 USA

[2] NEW YORK MED COLL, DEPT PATHOL, VALHALLA, NY 10595 USA

[3] UNIV CALIF SAN DIEGO, SCH MED, DEPT PHARMACOL, LA JOLLA, CA 92093 USA

[4] UNIV CALIF SAN DIEGO, SCH MED, DEPT NEUROSCI, LA JOLLA, CA 92093 USA

来源：

BRAIN RESEARCH | 1993年 / 606卷 / 02期

关键词：

CEREBELLUM; PURKINJE CELL; NON-ATAXIC; EXPLORATORY BEHAVIOR; TONIC-CLONIC SEIZURE; IMMUNE RESPONSE; GUINEA PIG;

D O I：

10.1016/0006-8993(93)91002-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This is the first description of GS guinea pigs, a partially inbred, non-ataxic, albino Peruvian (long-hair) strain with abnormal motor behavior and seizures. GS guinea pigs show gross and microscopic cerebellar and microscopic cerebrocortical abnormalities compared to Hartley strain animals. There is little difference between GS and short-hair guinea pig strains in Purkinje cell function, electrically evoked Ca2+ transients or immune responsiveness. The GS strain may prove useful in studying altered functions of the cerebellum in human disease.

引用

页码：325 / 331

页数：7

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