HOW MUCH HYDRATION IS NECESSARY FOR THE STABILIZATION OF DNA-DUPLEX

被引：28

作者：

MALTSEVA, TV ^{[1
]}

AGBACK, P ^{[1
]}

CHATTOPADHYAYA, J ^{[1
]}

机构：

[1] UNIV UPPSALA,CTR BIOMED,DEPT BIOORGAN CHEM,BOX 581,S-75123 UPPSALA,SWEDEN

来源：

NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 18期

关键词：

D O I：

10.1093/nar/21.18.4246

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A combination of NOESY and ROESY experiments show that the higher stabilities (T(m)) of phenazine tethered matched (2) and G-A mismatched (4) DNA duplexes are due to the decrease of the exchange-rate (i.e. increase of the life-time) of the imino-protons and the reduced water activity in their minor grooves compared to their non-tethered counterparts (1) and (3).

引用

页码：4246 / 4252

页数：7

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