NONPENETRANCE AND LATE APPEARANCE OF POLYPS IN FAMILIES WITH FAMILIAL ADENOMATOUS POLYPOSIS

被引：21

作者：

EVANS, DGR

GUY, SP

THAKKER, N

ARMSTRONG, JG

DODD, C

DAVIES, DR

BABBS, C

CLANCY, T

WARNES, T

SLOAN, P

TAYLOR, TV

HARRIS, R

机构：

[1] MANCHESTER ROYAL INFIRM,DEPT GASTROENTEROL,MANCHESTER M13 9WL,LANCS,ENGLAND

[2] MANCHESTER ROYAL INFIRM,DEPT SURG,MANCHESTER M13 9WL,LANCS,ENGLAND

[3] MANCHESTER ROYAL EYE HOSP,DEPT OPHTHALMOL,MANCHESTER,ENGLAND

[4] UNIV MANCHESTER,SCH DENT,DEPT ORAL MED,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

GUT | 1993年 / 34卷 / 10期

关键词：

D O I：

10.1136/gut.34.10.1389

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

One case of non-penetrance of the familial adenomatous polyposis (FAP) gene at 59 years of age and late onset of polyps on endoscopy and biopsy in this and two other families is described. Screening protocols should include dental screening as well as indirect ophthalmoscopy and endoscopy to detect minimal manifestations of the gene. In the absence of a specific DNA predictive test, bowel screening should continue well beyond 30 years of age.

引用

页码：1389 / 1393

页数：5

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