ARE FREE-RADICALS INVOLVED IN THE PATHOGENESIS OF IDIOPATHIC PARKINSONS-DISEASE

被引：12

作者：

POIRIER, J ^{[1
]}

THIFFAULT, C ^{[1
]}

机构：

[1] DOUGLAS HOSP, RES CTR, MONTREAL, PQ, CANADA

来源：

EUROPEAN NEUROLOGY | 1993年 / 33卷

关键词：

PARKINSONS DISEASE; FREE RADICALS; ANTIOXIDANTS; SUPEROXIDE DISMUTASE; BRAIN;

D O I：

10.1159/000118536

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Since the original description of Parkinson's disease (PD) more than 170 years ago, there have been major advances in the understanding and treatment of PD. This article reviews some current knowledge concerning the role of free radicals, especially superoxide, in the etiology of PD. Hypotheses regarding inhibition of mitochondrial respiration and free radicals generation in PD are discussed in relation to the mechanisms of action of the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a neurotoxin known to produce parkinsonian syndromes.

引用

页码：38 / 43

页数：6

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