ACUTE STRESS STIMULATES SECRETION OF GHRH AND SOMATOSTATIN INTO HYPOPHYSEAL PORTAL BLOOD OF CONSCIOUS SHEEP

被引：18

作者：

CATALDI, M

MAGNAN, E

GUILLAUME, V

DUTOUR, A

SAUZE, N

MAZZOCCHI, L

CONTEDEVOLX, B

OLIVER, C

机构：

[1] Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Intitut Fédératif Jean Roche, 13916 Marseille Cédex 20, Boulevard Pierre Dramard

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 01期

关键词：

GROWTH HORMONE RELEASING HORMONE; SOMATOSTATIN; GROWTH HORMONE; EMOTIONAL STRESS; SHEEP; HYPOPHYSEAL PORTAL BLOOD;

D O I：

10.1016/0304-3940(94)90300-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of acute stress on growth hormone (GH) secretion and the mechanisms involved in its changes have been investigated in sheep. An acute isolation-restraint stress induced a rapid and significant increase in jugular GH levels in 12 out of 14 rams. GH-releasing hormone (GHRH) and somatostatin secretion during the same stress were studied in 5 animals prepared for hypophysial portal blood collection. A 3.5-fold increase in portal GHRH levels was observed concomitantly with a slight elevation in portal somatostatin. Portal corticotropin-releasing hormone (CRH) and jugular cortisol plasma levels increased during the same stress. Our data suggest that an isolation-restraint stress stimulates GH secretion in the sheep and that GHRH may be responsible for GH response.

引用

页码：103 / 106

页数：4

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