ANTIBODY-STRUCTURE-BASED DESIGN OF PHARMACOLOGICAL AGENTS

被引：24

作者：

DOUGALL, WC ^{[1
]}

PETERSON, NC ^{[1
]}

GREENE, MI ^{[1
]}

机构：

[1] UNIV PENN, SCH MED, CTR RECEPTOR BIOL, DEPT LAB MED & PATHOL, PHILADELPHIA, PA 19104 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1994年 / 12卷 / 09期

关键词：

D O I：

10.1016/0167-7799(94)90038-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The well-studied antigen-combining sites of antibody molecules hold considerable promise as a model system for the design of bioactive peptides. These small, immunoglobulin-derived peptides can be used in the development of alternative treatments for disease and in diagnostic strategies. The general principles derived from the design of small pharmacological agents based on the structural features of antibodies may also be extended to the design of other bioactive peptides.

引用

页码：372 / 379

页数：8

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