VITAMIN-E AND THE HYPERCOAGULABILITY OF NEONATAL BLOOD

被引:8
作者
JAIN, SK [1 ]
MCCOY, B [1 ]
WISE, R [1 ]
机构
[1] LOUISIANA STATE UNIV, SCH MED, DEPT GYNECOL & OBSTET, SHREVEPORT, LA 71130 USA
关键词
VITAMIN E; NEWBORN INFANTS; WHOLE BLOOD CLOTTING TIME;
D O I
10.1016/0009-8981(94)90037-X
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
This study examines whether vitamin E deficiency has any role in the hypercoagulability of neonatal blood. Blood was collected from mothers and their full-term placental cords. Vitamin E was measured by high-pressure liquid chromatography and whole blood clotting time was measured by recalcification. Cord plasma had significantly lower vitamin E (P < 0.0001) compared with maternal plasma. Whole blood clotting time of cord blood was significantly (P < 0.002) shorter compared with the clotting time of maternal blood. There was a significant correlation between plasma vitamin E and whole blood clotting time (r = 0.54, P < 0.04) of cord blood. The addition of standard vitamin E to cord blood in vitro resulted in prolongation of whole blood clotting time. This suggests that a deficiency of plasma vitamin E can shorten whole blood clotting time in newborns, which may have a role in the disseminated intravascular coagulation frequently experienced by newborn infants.
引用
收藏
页码:97 / 103
页数:7
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