CHRONIC MYELOID-LEUKEMIA PRESENTING ALL-TYPE BCR/ABL TRANSCRIPT

被引：15

作者：

KUNIEDA, Y ^{[1
]}

OKABE, M ^{[1
]}

KUROSAWA, M ^{[1
]}

ITAYA, T ^{[1
]}

KAKINUMA, M ^{[1
]}

MIYAZAKI, T ^{[1
]}

机构：

[1] HOKKAIDO UNIV,INST IMMUNOL SCI,BACTERIAL INFECT SECT,SAPPORO,HOKKAIDO 060,JAPAN

来源：

ANNALS OF HEMATOLOGY | 1994年 / 69卷 / 04期

关键词：

PHILADELPHIA CHROMOSOME; CHRONIC MYELOID LEUKEMIA; PH1-POSITIVE LEUKEMIA; ALL-TYPE BCR/ABL MESSENGER-RNA; P190(BCR/ABL); THROMBOCYTOSIS; MYELOFIBROSIS;

D O I：

10.1007/BF02215952

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the breakpoints of the bcr gene in 46 Ph1-positive CML cases by Southern blot analysis of bet rearrangement, and in 17 CML cases by a combination of Southern blot analysis and RT-PCR. By Southern blot, the breakpoint was not identified on M-bcr in three CML cases, of which one case showed the P210-type bcr/abl transcript and two cases showed the ALL-type (P190-type) bcr/abl transcript with or without P210 transcript. Later two cases showed unique hematological profiles such as thrombocytosis, mild myelofibrosis, and relative resistance to alkylating agents. Therefore, the present study suggests that expression of the P190-type transcript may affect clinical and hematological findings in CML.

引用

页码：189 / 193

页数：5

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