SYNTHESIS OF ALPHA-SUBSTITUTED AND ALPHA,ALPHA-DISUBSTITUTED ALPHA-AMINO-ACID BY CONTROLLED MONOALKYLATION AND DIALKYLATION OF ETHYL N-DIPHENYLMETHYLENEGLYCINATE

被引：16

作者：

EZQUERRA, J ^{[1
]}

PEDREGAL, C ^{[1
]}

MORENOMANAS, M ^{[1
]}

PLEIXATS, R ^{[1
]}

ROGLANS, A ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,DEPT CHEM,E-08193 BARCELONA,SPAIN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(00)61378-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl N-diphenylmethyleneglycinate reacts with one equivalent of alkylating agents in the presence of powdered potassium carbonate to afford, after hydrolysis, monoalkylated glycine esters. A similar process using two equivalents of alkylating agents in the presence of powdered potassium hydroxide and a phase transfer catalysts gives, after hydrolysis, dialkylated glycine esters.

引用

页码：8535 / 8538

页数：4

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