UBIQUITINATED INCLUSIONS IN INCLUSION-BODY MYOSITIS PATIENTS ARE IMMUNOREACTIVE FOR CATHEPSIN-D BUT NOT BETA-AMYLOID

被引：18

作者：

SHERRIFF, FE ^{[1
]}

JOACHIM, CL ^{[1
]}

SQUIER, MV ^{[1
]}

ESIRI, MM ^{[1
]}

机构：

[1] RADCLIFFE INFIRM NHS TRUST,DEPT NEUROPATHOL,OXFORD OX2 6HE,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1995年 / 194卷 / 1-2期

关键词：

ALZHEIMERS DISEASE; AMYLOID BETA-PROTEIN; MUSCLE; UBIQUITIN; LYSOSOMES; HUMAN;

D O I：

10.1016/0304-3940(95)11718-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The nature of the inclusions in the human muscle disease inclusion-body myositis (IBM) has been the subject of debate. Parallels with Alzheimer's disease have been drawn after these inclusions were found to be ubiquitinated, and immunoreactive with antibodies to beta-amyloid (alpha beta) and certain amyloid-associated proteins. We have used a battery of antibodies against alpha beta and associated proteins to immunostain muscle biopsies from patients with IBM. Although the inclusions are ubiquitinated, we could not show immunoreactivity for alpha beta or the associated proteins investigated. We did, however, find that the ubiquitinated inclusions colocalised with the lysosomal marker, cathepsin D.

引用

页码：37 / 40

页数：4

共 33 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].

ABRAHAM, CR ;

SELKOE, DJ ;

POTTER, H .

CELL, 1988, 52 (04) :487-501

[2]

ALBRECHT S, 1993, ARCH PATHOL LAB MED, V117, P789

[3] IMMUNOLOCALIZATION OF UBIQUITIN IN MUSCLE BIOPSIES OF PATIENTS WITH INCLUSION BODY MYOSITIS AND OCULOPHARYNGEAL MUSCULAR-DYSTROPHY [J].

ASKANAS, V ;

SERDAROGLU, P ;

ENGEL, WK ;

ALVAREZ, RB .

NEUROSCIENCE LETTERS, 1991, 130 (01) :73-76

[4] APOLIPOPROTEIN-E IMMUNOREACTIVE DEPOSITS IN INCLUSION-BODY MUSCLE DISEASES [J].

ASKANAS, V ;

MIRABELLA, M ;

ENGEL, WK ;

ALVAREZ, RB ;

WEISGRABER, KH .

LANCET, 1994, 343 (8893) :364-365

[5] ENHANCED DETECTION OF CONGO-RED-POSITIVE AMYLOID DEPOSITS IN MUSCLE-FIBERS OF INCLUSION-BODY MYOSITIS AND BRAIN OF ALZHEIMERS-DISEASE USING FLUORESCENCE TECHNIQUE [J].

ASKANAS, V ;

ENGEL, WK ;

ALVAREZ, RB .

NEUROLOGY, 1993, 43 (06) :1265-1267

[6] PRION PROTEIN IS ABNORMALLY ACCUMULATED IN INCLUSION-BODY MYOSITIS [J].

ASKANAS, V ;

BILAK, M ;

ENGEL, WK ;

ALVAREZ, RB ;

TOME, F ;

LECLERC, A .

NEUROREPORT, 1993, 5 (01) :25-28

[7]

ASKANAS V, 1992, AM J PATHOL, V141, P31

[8] BETA-AMYLOID PRECURSOR EPITOPES IN MUSCLE-FIBERS OF INCLUSION-BODY MYOSITIS [J].

ASKANAS, V ;

ALVAREZ, RB ;

ENGEL, WK .

ANNALS OF NEUROLOGY, 1993, 34 (04) :551-560

[9]

ASKANAS V, 1994, AM J PATHOL, V144, P177

[10]

BERNSTEIN HG, 1989, J HIRNFORSCH, V30, P613

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