A 7-34 ANALOG OF THE PARATHYROID HORMONE-RELATED PROTEIN HAS POTENT ANTAGONIST AND PARTIAL AGONIST ACTIVITY INVIVO

被引：6

作者：

HORIUCHI, N ^{[1
]}

HONGO, T ^{[1
]}

CLEMENS, TL ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,DIV ENDOCRINOL,CTR BONE,LOS ANGELES,CA 90048

来源：

BONE AND MINERAL | 1991年 / 12卷 / 03期

关键词：

PARATHYROID HORMONE-RELATED PROTEIN; ANTAGONIST; HYPERCALCEMIA; BLOOD 1,25-DIHYDROXYVITAMIN-D;

D O I：

10.1016/0169-6009(91)90031-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The biological properties of a new synthetic analog of parathyroid hormone-related protein [PTHrP-(7-34)NH2] were examined in vivo using a well characterized thyroparathyroidectomized (TPTX) rat model. The phosphaturic and urine cyclic AMP response induced by infusion of PTHrP-(1-34)NH2 (0.16 nmol/h) was inhibited by 70% (P < 0.01, n = 6) by co-infusion of PTHrP-(7-34)NH2 at a 10-fold molar excess (1.6 nmol/h). The 7-34 PTHrP analog also antagonized the PTHrP-(1-34)NH2-induced hypercalcemia and rises in blood 1,25-dihydroxyvitamin D concentrations. However, when infused alone at a higher dose rate (8 nmol/h), PTHrP-(7-34)NH2 displayed significant PTH agonist activity. This profile contrasts to that of [Tyr-34]bPTH-(7-34)NH2 which is comparatively less potent (10-20-fold) with respect to its antagonist activity but has no appreciable agonist activity in vivo.

引用

页码：181 / 188

页数：8

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