A RAPID INCREASE IN LIPOPROTEIN (A) LEVELS AFTER ETHANOL WITHDRAWAL IN ALCOHOLIC MEN

被引：58

作者：

KERVINEN, K ^{[1
]}

SAVOLAINEN, MJ ^{[1
]}

KESANIEMI, YA ^{[1
]}

机构：

[1] UNIV OULU,DEPT INTERNAL MED,KAJAANINTIE 50,SF-90220 OULU,FINLAND

来源：

LIFE SCIENCES | 1991年 / 48卷 / 22期

基金：

芬兰科学院;

关键词：

D O I：

10.1016/0024-3205(91)90152-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Plasma concentrations of lipoprotein (a) (Lp(a)) were studied in 11 male alcoholics at the end of a drinking period and monitored during subsequent abstinence. Lp(a) levels showed a daily increase for four consecutive days after the beginning of abstinence, the values for the third and the fourth day being significantly higher than those of the first day (p < 0.05 and p < 0.01, respectively). The changes in Lp(a) showed no association with the changes in low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol levels. In one alcoholic subject with a heterozygous form of familial hypercholesterolemia who was monitored for 11 days, the Lp(a) levels rose up to the fourth day and remained at a high level thereafter. These results suggest that ethanol ingestion may be associated with a lowering of Lp(a) levels, which may contribute to the delayed progression of atherosclerosis observed in alcohol drinkers. Ethanol intake may be added to the short list of factors that affect the quite stable, genetically determined Lp(a) concentrations in the plasma.

引用

页码：2183 / 2188

页数：6

共 24 条

[1]

BARBORIAK JJ, 1979, J LAB CLIN MED, V94, P348

[2]

BERG K, 1963, ACTA PATHOL MIC SC, V59, P369

[3]

CASTELLI WP, 1977, LANCET, V2, P153

[4] EFFECT OF ACUTE INJECTIONS OF ETHANOL ON LIPID AND PROTEIN-BOUND SIALIC-ACID IN MICE OF DIFFERENT AGES [J].

CHERIAN, L ;

KLEMM, WR .

DRUG AND ALCOHOL DEPENDENCE, 1990, 26 (01) :29-34

[5] ASSOCIATION OF LEVELS OF LIPOPROTEIN LP(A), PLASMA-LIPIDS, AND OTHER LIPOPROTEINS WITH CORONARY-ARTERY DISEASE DOCUMENTED BY ANGIOGRAPHY [J].

DAHLEN, GH ;

GUYTON, JR ;

ATTAR, M ;

FARMER, JA ;

KAUTZ, JA ;

GOTTO, AM .

CIRCULATION, 1986, 74 (04) :758-765

[6] CORONARY HEART-DISEASE MORTALITY AND ALCOHOL-CONSUMPTION IN FRAMINGHAM [J].

FRIEDMAN, LA ;

KIMBALL, AW .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1986, 124 (03) :481-489

[7]

HABERLAND ME, 1989, CIRCULATION S2, V80, P163

[8] THE EFFECT OF CESSATION AND RESUMPTION OF MODERATE ALCOHOL INTAKE ON SERUM HIGH-DENSITY-LIPOPROTEIN SUBFRACTIONS - A CONTROLLED-STUDY [J].

HASKELL, WL ;

CAMARGO, C ;

WILLIAMS, PT ;

VRANIZAN, KM ;

KRAUSS, RM ;

LINDGREN, FT ;

WOOD, PD .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (13) :805-810

[9] OVEREXPRESSION OF HUMAN LOW-DENSITY-LIPOPROTEIN RECEPTORS LEADS TO ACCELERATED CATABOLISM OF LP(A) LIPOPROTEIN IN TRANSGENIC MICE [J].

HOFMANN, SL ;

EATON, DL ;

BROWN, MS ;

MCCONATHY, WJ ;

GOLDSTEIN, JL ;

HAMMER, RE .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) :1542-1547

[10] ACETALDEHYDE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN ACCELERATES ITS CATABOLISM IN MAN [J].

KESANIEMI, YA ;

KERVINEN, K ;

MIETTINEN, TA .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1987, 17 (01) :29-36

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