SOMATOSTATIN IN NEURODEGENERATIVE ILLNESSES

被引：25

作者：

BEAL, MF ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1990年 / 39卷 / 09期

关键词：

D O I：

10.1016/0026-0495(90)90226-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Somatostatin may play a role in several neurodegenerative diseases. Somatostatin concentrations are depleted in cerebral cortex in both Alzeheimer's disease and in the dementia that accompanies Parkinson's disease. Somatostatin neurons in both illnesses are markedly dystrophic and may be reduced in number. In Huntington's disease, somatostatin concentrations are increased in the basal ganglia, as is the density of somatostatin neurons. The precise role of somatostatin changes in the pathophysiology of these illnesses requires further study. © 1990.

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页码：116 / 119

页数：4

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