ABSENCE OF STRAND-SPECIFIC REPAIR OF CYCLOBUTANE PYRIMIDINE DIMERS IN ACTIVE GENES IN DROSOPHILA-MELANOGASTER KC CELLS

被引：9

作者：

DECOCK, JGR ^{[1
]}

KLINK, EC ^{[1
]}

LOHMAN, PHM ^{[1
]}

EEKEN, JCJ ^{[1
]}

机构：

[1] INTERUNIV RES INST RADIOPATHOL & RADIAT PROTECT,JA COHEN INST,LEIDEN,NETHERLANDS

来源：

MUTATION RESEARCH | 1992年 / 274卷 / 02期

关键词：

STRAND-SPECIFIC REPAIR; CYCLOBUTANE PYRIMIDINE DIMER; DROSOPHILA-MELANOGASTER;

D O I：

10.1016/0921-8777(92)90055-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Strand-specific excision repair of UV-induced cyclobutane pyrimidine dimers was investigated in three genes: Gart, Notch and white in the permanent Kc cell line derived from wild-type Drosophila melanogaster embryonic cells. In this cell line Gart and Notch are transcriptionally active, whereas white is not expressed. Cells were irradiated with 10 or 15 J/m2 ultraviolet (UV) light (predominantly 254 nm). In all three genes, cyclobutane pyrimidine dimers were removed from the non-transcribed strand at the same rate and to the same extent as from the transcribed strand, indicating the absence of strand-specific repair in permanent Drosophila embryonic cell lines.

引用

页码：85 / 92

页数：8

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