CLONING AND SEQUENCING OF A COUP TRANSCRIPTION FACTOR GENE EXPRESSED IN XENOPUS EMBRYOS

被引：32

作者：

MATHARU, PJ ^{[1
]}

SWEENEY, GE ^{[1
]}

机构：

[1] UNIV WALES COLL CARDIFF,DEPT BIOCHEM,POB 903,CARDIFF CF1 1ST,WALES

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1129卷 / 03期

关键词：

COUP TRANSCRIPTION FACTOR; STEROID THYROID RECEPTOR SUPERFAMILY; XENOPUS-LAEVIS;

D O I：

10.1016/0167-4781(92)90512-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA clone encoding COUP transcription factor, a member of the steroid/thyroid receptor superfamily, has been isolated from a Xenopus neurula (stage 17 embryo) library. Sequencing of this clone reveals an open reading frame encoding a 397 amino acid protein. The amino acid sequence of Xenopus COUP has been compared with its human and Drosophila homologues showing that there are few similarities within the amino-terminal region, whereas the remainder of the protein, including the putative DNA and ligand binding domains, is very well conserved.

引用

页码：331 / 334

页数：4

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