BMS-181184, A NEW PRADIMICIN DERIVATIVE - SCREENING, TAXONOMY, DIRECTED BIOSYNTHESIS, ISOLATION AND CHARACTERIZATION

被引：19

作者：

FURUMAI, T

SAITOH, K

KAKUSHIMA, M

YAMAMOTO, S

SUZUKI, K

IKEDA, C

KOBARU, S

HATORI, M

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, 2-9-3 Shimo-meguro, Tokyo, 153, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 02期

关键词：

D O I：

10.7164/antibiotics.46.265

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

BMS-181184 is a new semisynthetic pradimicin derivative with a broad-spectrum antifungal activity. In a search for actinomycetes producing BMS-181184, 4 strains of Actinoinadura sp. isolated from soil samples were found to produce the antibiotic under conditions of directed biosynthesis. Among them, Actinomadura sp. AB1236 proved most useful in the production of BMS-181184 when fermented in a medium containing D-serine and D-cycloserine. A minor product isolated from the broth of strain AB1236 was identified as the dexylosyl analog of BMS-181184, which was also obtained by acid hydrolysis of BMS-181184.

引用

页码：265 / 274

页数：10

共 27 条

[1]

Arai T., 1975, CULTURE MEDIA ACTINO

[2] RAPID DIFFERENTIATION BETWEEN NOCARDIA + STREPTOMYCES BY PAPER CHROMATOGRAPHY OF WHOLE-CELL HYDROLYSATES [J].