BAKERS YEAST-MEDIATED REDUCTION OF ALPHA-HYDROXY KETONES AND DERIVATIVES - THE STERIC COURSE OF THE BIOTRANSFORMATION

被引：24

作者：

FERRABOSCHI, P

GRISENTI, P

MANZOCCHI, A

SANTANIELLO, E

机构：

[1] Dipartimento di Chimica e Biochimica Medica, Università degli Studi di Milano, 20133 Milano, Via Saldini

来源：

TETRAHEDRON | 1994年 / 50卷 / 35期

关键词：

D O I：

10.1016/S0040-4020(01)89594-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The results from the baker's yeast-mediated reduction of the acetates 3a-d and the methyl ethers 5a-d were compared with the same biotransformation which converts the alpha-hydroxy ketones 1a-d into the (R)-diols 2a-d (90-98%ee); the acetates 3a-d afford the (S)-monoacetates 4a-d (72-94% ee) and the methyl ethers 5a-d are reduced to the (R)-monoethers 6a-d (64-76% ee).

引用

页码：10539 / 10548

页数：10

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