DEVELOPMENT OF ANTI-HUMAN-B BLOOD GROUP MONOCLONAL-ANTIBODIES SUITABLE AS A BLOOD TYPING REAGENT

被引：8

作者：

BECKER, MI ^{[1
]}

JUICA, F ^{[1
]}

JAMETT, A ^{[1
]}

TZICHINOVSKY, S ^{[1
]}

BARROS, S ^{[1
]}

AGUAYO, J ^{[1
]}

DEIOANNES, AE ^{[1
]}

机构：

[1] PONTIFICIA UNIV CATOLICA CHILE,FAC CIENCIAS BIOL,UNIDAD INMUNOL,SANTIAGO,CHILE

来源：

HYBRIDOMA | 1994年 / 13卷 / 04期

关键词：

D O I：

10.1089/hyb.1994.13.303

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An improved procedure for the generation of high-avidity anti-human B blood group monoclonal antibodies (MAbs) was developed. One of them, termed 7A1-2, showed excellent qualities of titer, avidity, and intensity required For use as human B blood typing reagent. Hemagglutination inhibition studies with monosaccharides and oligosaccharides were carried out to determine the specificity of the MAb 7A1-2. These studies indicate that the antibody reacts with the immunodominant region of the antigen which is known to confer the serologic specificity of this blood group.

引用

页码：303 / 310

页数：8

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