EFFECTS OF ACTIVIN-A ON DEOXYRIBONUCLEIC-ACID SYNTHESIS, IODINE-METABOLISM, AND CYCLIC ADENOSINE-MONOPHOSPHATE ACCUMULATION PORCINE THYROID-CELLS

被引：23

作者：

KOTAJIMA, A

MIYAMOTO, Y

TSURUO, M

KOSAKA, M

SAITO, S

机构：

来源：

ENDOCRINOLOGY | 1995年 / 136卷 / 03期

关键词：

D O I：

10.1210/en.136.3.1214

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

we have recently shown the presence of activin A in human thyroid cells. To determine whether activin A affects the growth and function of the thyroid, we investigated its effects on DNA synthesis, iodine metabolism, and cAMP accumulation in cultured porcine thyroid cells. Activin A increased DNA synthesis. This effect was abolished by addition of follistatin but additively enhanced by epidermal growth factor. In contrast, activin A significantly reduced uptake and release of iodide by the thyroid and also TSH-induced cAMP accumulation but did not inhibit the cAMP accumulation induced by forskolin. These data indicate that activin A stimulates thyroid growth irrespective of cAMP accumulation and inhibits thyroid function.

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页码：1214 / 1218

页数：5

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